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RUNX1 Early Career Investigator Grant

Grants to USA, Canada, and International
Investigators for Cancer Research Projects

Agency Type:

Foundation / Corporation

Funding Source:

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Alex's Lemonade Stand Foundation (ALSF) and RUNX1 Research Program (RRP)

Deadline Date:

12/16/19 11:59 PM ET

Description:

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Grants of up to $60,000 per year to USA, Canada, and International investigators at nonprofit institutions for cancer research projects. Funding is intended to support the work of early career scientists who have a doctorate and are within five years of a faculty appointment.

The key objective of this program is to promote the establishment of a new generation of translational and clinical researchers interested in tackling inherited hematologic malignancy predisposition disorders with a focus on RUNX1-familial platelet disorder. RPP believes that providing capital to early career investigators not only injects funding to where it is needed most, but also cultivates a new cohort of investigators who will be invested in an area of research that historically has had limited attention. The program also aims to support, inform, educate and connect patients and healthcare providers in the RUNX1 community.

The RUNX1 Early Career Investigator grant is a 3-year award designed to fund research in strategies leading to the development of therapies to prevent the transition from pre-leukemia to leukemia for patients with RUNX1-FPD. Collaboration and data sharing are a priority for this research program. The RUNX1 Research Program and ALSF host an annual scientific meeting that brings together grant recipients and other scientists. Grant recipients are expected to present their progress as part of the annual review. 

Aims of research proposals must be relevant to the ultimate goal of preventing hematologic malignant transformation in RUNX1-FPD. Proposals that seek to translate from bench to bedside will receive priority.

Example areas of research interests include:

  • Hematopoietic stem cell gene correction strategies that optimize gene editing efficiency, precision and limit off-target effects.
  • Determining the drivers of clonal hematopoiesis and disease progression.
  • Identifying strategies to lower the risk of hematologic malignancy in RUNX1-FPD.
  • Understanding the cellular and molecular mechanisms that underlie the inflammatory manifestations of RUNX1-FPD such as eczema and psoriasis.

GrantWatch ID#:

GrantWatch ID#: 187469

Estimated Size of Grant:

A RUNX1 Early Career Investigator Grant is $180,000 over 3 years (maximum $60,000 per year may be requested).

Term of Contract:

The RUNX1 Early Career Investigator grant is a 3-year award starting in June 2020 and ending in May 2023.

Additional Eligibility Criteria:

- Applicants must have an M.D., Ph.D. or dual M.D., Ph.D. (D.O., MBBS or equivalent) and be within 5 years of their first faculty appointment as an Assistant Professor or equivalent. Associate and Full Professors are ineligible. If still at the Instructor level, the applicant must have a commitment from the Department Chair/Division Chief at the time of grant submission for an Assistant Professor position within one year of receiving the award.
- A minimum of 75% of the applicant’s time during the award period must be allocated as protected time
for all research activities. This percentage of time includes both activities on this grant and the applicant’s
other research responsibilities.
- Applicants may have research grants from other funding sources during the award period, but there must
be clear documentation of mechanisms to avoid scientific and budgetary overlap.
- Applicants must have research experience working in and a deep understanding of normal or malignant
hematopoiesis and/or immunology.
- Applicant institutions may be based in the U.S. or outside of the U.S. Applicants need not be United States citizens. Funds must be granted to non-profit institutions or organizations.
- One resubmission of a previously unfunded application is allowed. Use the Resubmission section of the
application to respond to the prior RRP/ALSF critique of the proposal. The response will be scored in the
review process in addition to the criteria used for new applications. Resubmissions compete with new
applicants for funding
- Funds may not be used for research utilizing human embryonic stem cells or non-human primates.
Research with human induced pluripotent stem cells is permissible.

Pre-Application Information:

Application Due Date: December 16th (11:59 PM ET)
Award Notification Date: April 2020
Project Start Date: June 1, 2020
Project End Date: May 31, 2023
RPP Annual Scientific Meeting: Annually in October

Three letters of recommendation must be submitted on behalf of the applicant.

Contact Information:

Before starting your grant application, please review the funding source's website listed below for updates/changes/addendums/conferences/LOIs.

To register for online application and to apply online, click here: https://alsfapps.force.com/FGM_Portal__CommunitySignin

For questions regardign eligiblity or research proposal topics, please contact RPP at info@runx1-fpd.org.

All other questions can be submitted to Carrie Peck at 866-333-1213 or by email Grants@AlexsLemonade.org.

URL for Full Text (RFP):

Geographic Focus:

USA: Alabama;   Alaska;   Arizona;   Arkansas;   California;   Colorado;   Connecticut;   Delaware;   Florida;   Georgia;   Hawaii;   Idaho;   Illinois;   Indiana;   Iowa;   Kansas;   Kentucky;   Louisiana;   Maine;   Maryland;   Massachusetts;   Michigan;   Minnesota;   Mississippi;   Missouri;   Montana;   Nebraska;   Nevada;   New Hampshire;   New Jersey;   New Mexico;   New York City;   New York;   North Carolina;   North Dakota;   Ohio;   Oklahoma;   Oregon;   Pennsylvania;   Rhode Island;   South Carolina;   South Dakota;   Tennessee;   Texas;   Utah;   Vermont;   Virginia;   Washington, DC;   Washington;   West Virginia;   Wisconsin;   Wyoming

USA Territories: American Samoa (USA)   Guam (USA)   Puerto Rico (USA)   Virgin Islands (USA)   Northern Mariana Islands (USA)

USA Compact Free Associations: The Federated States of Micronesia (USA)   Marshall Islands (USA)   Republic of Palau (USA)

Canada: Alberta   British Columbia   Manitoba   New Brunswick   Newfoundland and Labrador   Northwest Territories   Nova Scotia   Nunavut   Ontario   Prince Edward Island   Quebec   Saskatchewan   Yukon

Israel

International country outside of the USA, Israel and Canada.